This thread is a little old but hopefully it’s somewhat useful information. I was on Prolia for awhile, I had a total of 4 injections, every 6 months. During early winter of this year, I overate Doritos and injured my mouth while eating them. A month or so later, my oral surgeon discovered exposed bone in my mouth (just a tiny little thing) probably from the injury from Doritos. The second oral surgeon I was sent to didn’t see any infection but started me on an antibacterial mouthwash.
Prolia has a half life of 6 months. That means that the bone is redeveloping every six months. The first month after the shot is when the growth the fastest and then the growth tapers down for the next 5 months.
The cut in my mouth allowed the growing bone to surface in my mouth, The fifth month after receiving my last Prolia shot was terribly painful. The little tiny exposed bone caused much agony for me. I was given Gabapentin for nerve pain along with Tylenol, around the clock. Then later, after a hard lump developed under my chin with swelling and hot to the touch, I was given Clindamycin, an antibiotic.
I am pain free now and holding my breath that I don’t have to go through that again.
Anyway, I do believe in Prolia, my last DEXA scan did show a nice increase in bone strength but that will begin to fade because I am not getting any more Prolia shots. I just wanted to point out that there is a possibility of getting jaw necrosis with Prolia. Also, be aware that mouth injuries and Prolia can be very painful and can be very serious.